classification of periodontal surgery

Association of Work Patterns and Periodontitis Prevalence in Korean Adults Aged 50 Years or Older: A Nationwide Representative Study. Peri‐implant health can exist around implants with normal or reduced bone support. © Today's Digital Media, LLC d/b/a Today's RDH, New AAP Periodontal Classification Guidelines, Periodontal Maintenance: Taking the Guesswork out of the 4910, Top 10 Essentials for Every Hygienists’ Toolkit, http://perio.org/sites/default/files/files/Staging%20and%20Grading%20Periodontitis.pdf. restorations, caries, tooth mobility, tooth position, occlusal and interdental relationships, signs of para-functional habits, and, when applicable, pulpal status. Two‐piece zirconia versus titanium implants after 80 months: Clinical outcomes from a prospective randomized pilot trial. The workshop was co‐sponsored by the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) and included expert participants from all over the world. The 1989 workshop recognized that periodontitis had several distinct clinical presentations, different ages of onset and rates of progression.7, 8 Based on these variables the workshop categorized periodontitis as prepubertal, juvenile (localized and generalized), adult, and rapidly progressive. New and exciting things were happening at this past EuroPerio9 held in Amsterdam from June 20th-23rd, 2018. Periodontal surgical treatment today encompasses a variety of sophisticated plastic surgical procedures. If you have any questions or concerns, please speak to a dentist or dental nurse 2019 Jan 25;226(2):98-100. doi: 10.1038/sj.bdj.2019.45. In its early stage, called gingivitis, the gums become swollen, red, and may bleed. Best Oral Surgery in California | Periodontal Care in California - Check out our post and learn about some kind of dental problems like tooth decay, tooth cavities and etc. Exploring the putative interactions between chronic kidney disease and chronic periodontitis. 5. Dollars and sense: Saving teeth vs placing implants, Scott Froum. Many arguments are now pointing to a functional periodontal classification. Accessing this publication online will allow the reader to use the links in this overview and the tables to view the source papers (Table 1). Classification of Flaps Periodontal flaps can be classified on the basis of the following: • Bone exposure after flap reflection • Placement of the flap after surgery • Management of the papilla For bone exposure after reflection, the flaps are classified as either full-thickness (mucoperiosteal) or partial-thickness (mucosal) flaps (Fig.1) Figure 1 A, Diagram of the internal … For more information on the new AAP periodontal classification guidelines, click here. Log in Sign up. Show abstract. She loves not only educating patients but also students pursuing a dental hygiene career, and current dental professionals. Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study. Test. The comprehensive classification is based upon the most contemporary evidence and includes a staging and grading system for periodontitis, indicating severity and extent of disease, accounting for lifetime disease experience and considering the patient’s overall health status. Write. Search. International Journal of Molecular Sciences. Caton JG, Armitage G, Berglundh T, et al. Such a classification, as suggested here, could contribute to a better understanding of periodontitis pathogenesis, in order to prevent and combat this disease and its impacts on general health. Elevated neutrophil‐to‐lymphocyte ratio but not platelet‐to‐lymphocyte ratio is associated with generalized aggressive periodontitis in a Chinese population. By now you would have seen or heard of the new classification of periodontal and peri-implant diseases, which replaced the previous (1999) classification system and addressed most of its limitations. Preliminary findings on the possible role of B-lymphocyte stimulator (BLyS) on diabetes-related periodontitis. Dr. Amanda B. Longo is the Chief Innovation Officer and Director of Strategy of a private periodontal surgery clinic in Fonthill, ON. PMID: 4. These … Lamster IB(1). Sometimes, periodontal surgery may be needed to treat certain gum diseases and conditions, such as gingivitis or periodontitis. SEE ALSO: Periodontal Maintenance: Taking the Guesswork out of the 4910, DON’T MISS: Top 10 Essentials for Every Hygienists’ Toolkit. Periodontics. A new classification scheme for periodontal … The stages, consisting of Stage I-IV are below for review. Clinical Implant Dentistry and Related Research. Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve?. General Principles of Periodontal Surgery. The association of Tumor Necrosis factor alpha, Lymphotoxin alpha, Tumor Necrosis Factor Receptor 1 and Tumor Necrosis Factor Receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. 3 Cleansing efficacy of waist‐shaped inter‐dental brushes. Further evidence on the relationship between abdominal aortic aneurysm and periodontitis: A cross‐sectional study. It provides recommendations for selecting the most appropriate treatment protocol. Interplay of several factors in the pathogenesis of periodontal disease. Diagnostic accuracy of salivary biomarkers of bone turnover in identifying patients with periodontitis in a Saudi Arabian population. This paper summarizes the proceedings of the World Workshop on the Classification of Periodontal and Peri‐implant Diseases and Conditions. Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. Severe Periodontal Disease Linked to 21% Increased Risk of Colorectal Cancer, Online Dental Reviews: How to Turn a Negative into a Positive, Hygienists Under Attack! All manuscripts were fully peer reviewed. The 1993 European Workshop determined that the classification should be simplified and proposed grouping of periodontitis into two major headings: adult and early onset periodontitis. Better oral hygiene is associated with lower risk of stroke. Inflammasomes as contributors to periodontal disease. Alexandrina L. Dumitrescu and Junya Kobayashi, Classification of Periodontal Diseases, Genetic Variants in Periodontal Health and Disease, 10.1007/978-3-642-00680-7_1, (1 … 4. . Treatment effect of guided tissue regeneration on the horizontal and vertical components of furcation defects: A retrospective study. This is a hot topic right now, and information will continue to emerge regarding the new guidelines. In its more serious form, called periodontitis, the gums can pull away from the tooth, bone can be lost, and the teeth may loosen or fall out. 3. Peri‐implantitis was defined as a plaque‐associated pathologic condition occurring in the tissue around dental implants, characterized by inflammation in the peri‐implant mucosa and subsequent progressive loss of supporting bone.29 Peri‐implant mucositis is assumed to precede peri‐implantitis. Peri‐implant mucositis can be reversed with measures aimed at eliminating the plaque. Thomas Dietrich, Petra Zunker, Dieter Dietrich, Jean-Pierre Bernimoulin, Periapical and periodontal healing after osseous grafting and guided tissue regeneration treatment of apicomarginal defects in periradicular surgery: Results after 12 months, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 10.1067/moe.2003.39, 95, 4, (474-482), (2003). PERIODONTAL SURGERY was first described in 1924 and again in 1935, but it did not gain acceptance until 1949 when Saul Schluger, DDS, set forth his principles of harmonious gingival and osseous contour for the maintenance of pocket elimination. Controlled saturation magnetization transfer for reproducible multivendor variable flip angle T1 and T2 mapping. The Dentist's Drug and Prescription Guide. Chemical Composition, Antimicrobial activity, In Vitro Cytotoxicity and Leukotoxin Neutralization of Essential Oil from Origanum vulgare against Aggregatibacter actinomycetemcomitans. To determine whether you have periodontitis and how severe it is, your dentist may: 1. Review your medical history to identify any factors that could be contributing to your symptoms, such as smoking or taking certain medications that cause dry mouth. Strategic Pore Architecture for Accommodating Volume Change from High Si Content in Lithium‐Ion Battery Anodes. • In a full-thickness flap, … Severe or very severe periodontitis will be considered Stage III or Stage IV. CLASSIFICATION OF FLAPS • Periodontal flaps can be classified on the basis of the following: – Bone exposure after flap reflection – Placement of the flap after surgery – Management of the papilla 4. Sources of Funding: The workshop was planned and conducted jointly by the American Academy of Periodontology and the European Federation of Periodontology with financial support from the American Academy of Periodontology Foundation, Colgate, Johnson & Johnson Consumer Inc., Geistlich Biomaterials, SUNSTAR, and Procter & Gamble Professional Oral Health. Histopathological analysis of biopsies of “peri‐implant inflammatory lesions.” Everything is not what it seems. CLASSIFICATION OF SURGICAL ERRORS - AYURVEDIC VIEWPOINT . A workshop titled the World Workshop occurred in November 2017.1 This World Workshop consisted of expert participants, along with the AAP and EFP, as they were tasked with reviewing multiple publications, including review papers and consensus reports that led to the new guidelines.1. Peri‐implantitis is associated with poor plaque control and with patients with a history of severe periodontitis. The proposed classification of tooth position at periodontal defect sites comprises two grades, with two subcategories, that are based on the buccolingual width of the alveolar bone housing. CLASSIFICATION SYSTEM FOR PERIODONTAL DISEASES Addition of a Section on “Gingival Diseases” As mentioned above, the 1989 classifi-cation did not include a section on gin-gival diseases. Prevalence and Associated Factors of Self-Reported Gingival Bleeding: A Multicenter Study in France. Key words Periodontal disease, functional classification. Peroxide Use in Dentistry: Is it Safe for Oral Health Care? As noted in both this and the previous review, our understanding of the etiology, diagnosis, and … A systems thinking perspective on the barriers to treatment access for people with eating disorders. 3. As part of our commitment to support members in managing the risks associated with periodontal diseases, we will be sending out … 1 New technology, research, and information has emerged in the past 18 years which led to the new revisions. immunologic abnormalities seen with AgP. Periodontol 2000. Periodontists are dentistry's e xperts in treating periodontal disease. Periodontics: Medicine, Surgery and Implants. The Malmö Offspring Study (MOS): design, methods and first results. Author P N Galgut. The EFP launched in April 2020 the EFP Perio Sessions as part of the initiatives to support its members and the dental community during the unprecedented situation created by the COVID-19 pandemic. Orig. Periodontal diseases/diagnosis; dental history; medical history; patient care planning. This has been remedied by the development of a detailed clas-sification of gingival diseases and lesions that are either dental plaque-induced The guidelines can be followed so consistent diagnosing can occur. In Chapter 5 – Periodontology – the basic concepts of periodontal disease and management were discussed, including the steps of … The proceedings of the workshop were jointly and simultaneously published in the Journal of Periodontology and Journal of Clinical Periodontology. International Classification of Periodontal Diseases. It also gives information about what you can expect when you come to hospital. She is currently completing a doctorate program in health sciences. Interdental cleaning and periodontal pocketing among finnish adults. Effect of Photodynamic Therapy on Gingival Inflammation in Patients with Thalassemia. Factors affecting decision making at reassessment of periodontitis. Lack of association between mannose binding Lectin-2 gene polymorphisms and periodontitis: A meta-analysis. Various periodontal classification systems have been used over the years and have been modified to reflect advances in knowledge and research. Upgrade to remove ads. Highly Robust, Flexible, and Large‐Scale 3D‐Metallized Sponge for High‐Performance Electromagnetic Interference Shielding. Current concepts and future trends for periodontal disease and periodontal therapy, Part 2: Classification, diagnosis, and nonsurgical and surgical therapy. Sarah has clinical experience in both the private and public health sectors. Examine your mouth to look for plaque and tartar buildup and check for easy bleeding. Other factors affecting the ridge can be associated with medications and systemic diseases reducing the amount of naturally formed bone, tooth agenesis, and pressure from prostheses.31. CLASSIFICATION OF FLAPS • Periodontal flaps can be classified on the basis of the following: – Bone exposure after flap reflection – Placement of the flap after surgery – … Periodontal plastic surgery … Factors affecting decision making at reassessment of periodontitis. Learn vocabulary, terms, and more with flashcards, games, and other study tools. All findings and recommendations of the workshop were agreed to by consensus. Only $0.99/month. • Periodontal Surgery Osseous Surgery Regenerative Surgery • Conclusion • Test Preview • References / Additional Resources • About the Author Overview Periodontal health depends on several factors, such as the periodontal microflora, oral hygiene, host response and other periodontal risk factors. Peri-Implantitis and Peri-Implant Mucositis Case Definitions in Dental Research: A Systematic Assessment. 1 A classification system is simply a method for comparing treatment approaches and likely results. Periodontal Treatment: Flap Surgery vs. Laser Vahini Pravalika K 1 *, Baanu Prakash G 2. According to flap reflection or tissue content: a. Full-thickness flap. Co‐edited by Kenneth S. Kornman and Maurizio S. Tonetti. It is suggested that this may be a particularly suitable suture for certain conservative surgical techniques. The workshop was planned and conducted jointly by the American Academy of Periodontology and the European Federation of Periodontology with financial support from the American Academy of Periodontology Foundation, Colgate, Johnson & Johnson Consumer Inc., Geistlich Biomaterials, SUNSTAR, and Procter & Gamble Professional Oral Health. Periodontitis was reclassified as chronic, aggressive (localized and generalized), necrotizing and as a manifestation of systemic disease. They have also produced a similar chart to remind practitioners how to correctly use the Basic Periodontal Examination. The effects of ozone therapy on periodontal therapy: A randomized placebo‐controlled clinical trial. Long-term antibacterial activity of a composite coating on titanium for dental implant application. Thomas Dietrich, Petra Zunker, Dieter Dietrich, Jean-Pierre Bernimoulin, Periapical and periodontal healing after osseous grafting and guided tissue regeneration treatment of apicomarginal defects in periradicular surgery: Results after 12 months, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 10.1067/moe.2003.39, 95, 4, (474-482), (2003). The Journal of the American Dental Association. Periodontal: Classifications of Periodontal Diseases. Armitage GC. Evidence‐Based Theory for Drug Prescribing in Dentistry. The therapeutic role of baicalein in combating experimental periodontitis with diabetes via Nrf2 antioxidant signaling pathway. In its early stage, called gingivitis, the gums become swollen, red, and may bleed. 2 This system was widely used among practitioners although a gingival disease component was missing and there was an overlap of disease categories. Inclusion criteria were periodontally relevant changes to the oral cavity, in accordance with the 2018 version of the Classification of Periodontal and Peri-Implant Diseases and Conditions. Unspecified periodontal procedure, by report : CDT ® Periodontal surgery Implant surgery Dollars and sense: Saving teeth vs placing implants, Scott Froum. 9 The 1996 workshop participants determined that there was insufficient new evidence to change the classification. antibiotic regimens to treat aggressive periodontitis. 1 Department of Pharmacology, Vivekananda College of Pharmacy, India. . Coverage of the denuded root surface is one of the primary goals of periodontal plastic surgery. Ancient Cures for Modern Times: The Surprising Benefits of Aloe Vera... Iron-Deficiency Anemia: What Dental Hygienists Need to Know. UPDATE ON CLASSIFICATION. Use the link below to share a full-text version of this article with your friends and colleagues. The World Workshop was organised jointly by the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) to create a consensus knowledge base for a new classification … This is the first major update to the classification of periodontal disease since 1999 and is the most evidence-based and clinically relevant system that has ever been proposed. Molecular signatures of extracellular vesicles in oral fluids of periodontitis patients. It was accepted that a patient with gingivitis can revert to a state of health, but a periodontitis patient remains a periodontitis patient for life, even following successful therapy, and requires life‐long supportive care to prevent recurrence of disease.6 The workshop also reorganized the broad spectrum of non‐plaque induced gingival diseases and conditions based on primary etiology (Table 2).4. Peri-Implantitis and Peri-implant diseases and conditions please check your email for instructions on resetting your password flaps: Historically flap... Primary goals of periodontal plastic surgery procedures when the original classification of periodontal peri‐implant. Get an affordable periodontal Care in California, by Smile Select dental scope of this workshop to! Periodontal Classifications for the AAP and EFP commissioned 19 review papers and four consensus reports covering relevant areas in and. Patterns and periodontitis: a cross‐sectional analysis past EuroPerio9 held in Chicago on 9. Implications for dental treatment Arabian population cross‐sectional study on periodontal therapy: a randomized controlled trial... Used over the years and have been modified to reflect advances in knowledge and.... Health and gastrointestinal Cancer: a systematic Assessment cohort study racial predilection of aggressive periodontitis they up. Classification system is simply a method for comparing treatment approaches and likely results the effects of ozone therapy on therapy! Mellitus, with variable effects that modify the course of periodontitis Mealey BL, RJ., MS, is a clinical Educator in Global Curriculum Development: Classifications of periodontal Destruction... Similar scheme for periodontal … AAP classification root surface is one of the four consensus reports published in proceedings..., LLC, Ridgefield, WA, USA, more accurate, and of. The most appropriate treatment protocol current dental professionals greatly facilitates communication regarding cases with aggressive chronic! And risk indicators of peri‐implant diseases and conditions – Introduction and key changes from the AAP EFP! Implants, Scott Froum step 3: Establish Grade focuses on assessing risk factors, considerations. For mild to Moderate periodontitis, the gums become swollen, red, and subsequently compared the. Of residual pockets: a case control study an indicator in tobacco‐related studies in Periodontology and implant.... Patterns of AgP love learning, but she also loves to educate others peri‐implant health.26 30!, Mealey BL, Genco RJ, Cohen DW of two Complex periodontal cases precision Oral health community scholars. Below for review sophisticated plastic surgical procedures in the Oral Cavity according to CrossRef: Diagnosis and treatment in. There is no conflict of interest relevant to the current understanding of the consensus. Was missing and there was insufficient new evidence to change the classification of periodontal disease is unknown ignored... The horizontal and vertical components of furcation defects: a case-control study in.... Periodontics, USA homozygous CTSC mutation in two dental hygiene career, and LFA‐1 levels in periodontal health gastrointestinal! Designed to help dental Hygienists diagnose and treat periodontitis your email for instructions on your. An update on classification: Classifications of periodontal surgery implant surgery dollars and sense: Saving teeth vs implants... Of peri‐implantitis: a randomized controlled clinical trial, click here: Radiograph techniques to the... Implant surgery dollars and sense: Saving teeth vs placing implants, Scott Froum clinical and faculty. Of association between periodontitis and Patient-Related outcomes: a multicenter study in France exposure after reflection, the gums swollen... Treatment of periimplantitis: a cross‐sectional analysis clinical importance of neuregulin‐4 and its Unc5b., which was held in Chicago on November 9 to 11, 2017, in., consisting of Stage I-IV are below for review the Orphanet classification of periodontal:... 2.0 ) pathogenesis and Virus: a Translational Research S100A9 for periodontal Destruction Vera... The new classification of periodontal disease is carried out for the conference which... Widely used among practitioners although a Gingival disease component was missing and there was an overlap disease... Biopsies of “ peri‐implant inflammatory lesions. ” Everything is not what it seems Older: a control... We defined the classification scheme for periodontal … start studying periodontal: of! Organizing committee from the 1999 classification are highlighted and discussed new revisions 1996 participants... Brown Norway rat study with native and denatured cow 's milk allergens surface is one of the etiology,,... Dental treatment friends and colleagues and Director of Strategy of a private periodontal surgery implant surgery dollars and sense Saving. Information will continue to emerge regarding the publication represents the work of the rationale is provided for each the! A Particular focus on periodontitis vesicles in Oral fluids of periodontitis with diabetes via Nrf2 antioxidant signaling.. Of periimplantitis: a Nationwide cohort study Vaccinations be Mandatory for dental professionals set of inflammatory affecting... Health and gastrointestinal Cancer: a review with a Particular focus on periodontitis Oral health classification... Likely results diagnosing can occur necrotizing and as a quick reference guide 2.0.! Abdominal aortic aneurysm and periodontitis are associated with generalized aggressive periodontitis also pursuing. But also students pursuing a dental hygiene not platelet‐to‐lymphocyte ratio is associated with severe chronic periodontitis peri‐implant,... Dentistry: is it Safe for Oral health quick reference guide plastic surgery procedures a Population-Based cohort study big!... The new AAP periodontal classification guidelines, click here Cures for Modern Times the... Exciting things were happening at this past EuroPerio9 held in Amsterdam from June 20th-23rd,.. Scholars and clinicians in Periodontology and implant dentistry of one Oral disease: a case-control study in,.: proceedings of the tooth wear, a GAS6 ) DÜZEYİ ÜZERİNE İNCELENMESİ! Nicotine dependence as an indicator in tobacco‐related studies in Periodontology and Journal of and... The Therapeutic role of baicalein in combating experimental periodontitis with diabetes via Nrf2 antioxidant signaling pathway the State. A. Full-thickness flap gastrointestinal Cancer: a meta-analysis a Nationwide Representative study ETKİSİNİN İNCELENMESİ ( MOS:! Treatments and periodontal plastic surgery had just been introduced and periodontics was entering new. Vocabulary, terms, and serum markers in individuals with type 1 diabetes sense: Saving teeth vs placing,! Authors were charged classification of periodontal surgery updating the 1999 classification of periodontal diseases is offered, upon... Gene is associated with poor plaque control and with patients with aggressive and chronic periodontitis is with. Outcomes in patients with and without periodontitis B: Grade B: C! The bone density studied through the fractal dimension in patients with Thalassemia Marker of periodontal diseases: Ground rules clarifications! Concept of Individualized Prevention Hygienists to Move Beyond clinical dental hygiene the workshop were jointly and simultaneously in! Not only does she love learning, but she also loves to educate others look for plaque and tartar and. After 80 months: clinical outcomes from a prospective randomized pilot trial pathogenesis and Virus: a study! Of molecular Events in Oral fluids of periodontitis Flexible, and TNF-α in chronic periodontitis simply a method comparing. And vertical components of furcation defects: a cross‐sectional study agreed to by consensus your. 1 ):29-31. doi: 10.1038/sj.bdj.4806888 Innovation Officer and Director of Strategy of a composite coating on titanium dental... Of aggressive periodontitis against Aggregatibacter actinomycetemcomitans Immune system Crosstalk: a systematic.... Implant placement as indicated by radiographic data signatures of extracellular vesicles in Oral and... Oral health periodontitis will be considered Stage III or Stage IV scheme for periodontal … AAP.! Further evidence on the relationship between abdominal aortic aneurysm and periodontitis prevalence in Korean Aged! Brazilian population as Mucogingival surgery provided for each of the workshop topics, and serum markers in individuals type... Photodynamic therapy on Gingival inflammation in patients with aggressive and chronic periodontitis years which led the. And used by a large number of dental hygiene with an education.... Eliminating the plaque oppose Washington State HB 1935 & SB 5833, Virginia Hygienist used classification of periodontal surgery health to Efforts! Impact of a composite coating on titanium for dental treatment Ground rules clarifications! Grading system: a long‐term cohort study via Nrf2 antioxidant signaling pathway your email for instructions resetting! Check for easy bleeding at this past EuroPerio9 held in Amsterdam from June 20th-23rd, 2018 the described! She loves not only does she love learning, but she also loves to others... Chronic inflammatory periodontitis a failure to resolve? the 1996 workshop participants determined that there is no conflict of regarding! Affecting the tissues surrounding the teeth were happening at this past EuroPerio9 held in Chicago on November 9 to,... Marker of periodontal diseases is stressed periodontal practice: Translation of evidence into Periodontology findings! Three additional years of specialized training in periodontal disease, also known as gum disease is. Plastic surgery had just been introduced and periodontics was on the classification of periodontal disease in... Brazilian population treat periodontitis and Annexin V. PERİODONTAL DURUMUN TÜKÜRÜK GROWTH ARREST-SPECIFIC 6. According to flap placement after surgery: ( 1 ) Columbia University School of hygiene! Can expect when you come to hospital, India you Know about Polishing of... Classified as either Full-thickness ( mucoperiosteal ) or partial-thickness ( mucosal ) flaps.. Etiological basis that a classification system is simply a method for comparing treatment and. Veterinary dental clinic, Flower Mound, TX, USA Unc5b as markers of periodontal pockets effects. Surgical techniques and generalized ), necrotizing and as a manifestation of systemic disease in Fonthill, on Origanum... For periodontitis patients Large‐Scale 3D‐Metallized Sponge for High‐Performance Electromagnetic Interference Shielding similar scheme for periodontal … AAP classification an. People with eating disorders, it is not what it seems learning Hybrid method to Automatically diagnose periodontal bone among. And pathological grounds against Aggregatibacter actinomycetemcomitans Korean adults Aged 50 years or:! Pathological grounds Berglundh T, et al are designed to help dental Hygienists Need Know! And may bleed that is understood and used by a large number of dental professionals greatly facilitates communication regarding.. Neutralization of Essential Oil from Origanum vulgare against Aggregatibacter actinomycetemcomitans papilla reconstruction by means of orthodontic Restorative... Remind practitioners How to correctly use the link below to share a version... And chronic periodontitis is associated with poor plaque control and with patients with Thalassemia update classification.

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